adapalene vs tretinoin

& MHRA (C42990). It's also known for requiring a purge period, meaning it will often make your acne worse before it starts getting better. Differin redness. Because of this, if you have sensitive skin that gets irritated, itchy or uncomfortable easily, you may be better suited for the less irritating nature of adapalene over tretinoin. It is also associated with less irritation than tretinoin. While tretinoin and adapalene have numerous similarities when it comes to treating acne, the two drugs are very different as anti-aging treatments. Get to clear skin with the Clear90 app. Unlimited visits. Acne is one of the most common skin conditions in the world. Scott is one of the two founders of The Independent Pharmacy. This article is for informational purposes only and does not constitute medical advice. It is not intended for customer support. A comparison of Differin and Tretinoin, both Retinoids, and which one is best for Acne, Ageing, etc. Dr Don Grant is a GP with over 30 years experience and is the Clinical Advisor at The Independent Pharmacy. Tretinoin and adapalene are both highly effective at treating acne. Beyond the “purge” and mild side effects, the major disadvantages of tretinoin are its effects on your skin’s sensitivity to sunlight. To make things easier here’s a brief summary of popular treatments you can use: Ultimately, the treatment you should use for your acne will depend not only on the severity and nature of your symptoms but also on how you react to different treatments. And Adapalene is the synthetic form of Retin-A. Retin-A vs. Tretinoin . Proactiv vs. Unblemish: What Works Best for Acne? Talk to a doctor now. More than 70% of patients in both groups had complete clearance or marked improvement. If needed, Differin can be used with an oral antibiotic such as Tetralysal 300 for an additive effect if you suffer from moderate to severe acne with significant redness or inflammation. Are you interested in using tretinoin to prevent acne and reverse the signs of aging? There are also a few practical advantages to adapalene: It is most effective as a treatment for acne, but can also help with wrinkles and sun damage. For most people, the best choice is to talk to your healthcare provider about the two medications and work together to choose the best option for your specific needs. Thirty-six patients continued the trial for the 12-month duration. A 52-week study of adapalene 0.3 percent gel (the higher, prescription-only concentration of topical adapalene) found that only 21 percent of users experienced side effects from the treatment, of which the most common were dry skin, scaling and skin discomfort. Our Tretinoin 101 guide, linked below, lists many of these studies, with plenty of data on how and why tretinoin works as an acne and anti-aging medication. Both adapalene and tretinoin produce dramatic reductions in total, inflammatory and non-inflammatory lesion counts, in the range of 69-74% on average. First, adapalene can inhibit keratinocyte differentiation, making it helpful for decreasing microcomedone formations, treating inflammation and exfoliating mature comedones. Adapalene is better than tretinoin at targeting the causes of acne. Tretinoin (Retin-A, generic), tazarotene (Avage, Tazorac), and adapalene (Differin) are prescription retinoids. Differin (Adapalene) and Epiduo are two gels used for acne treatment. Differin, the once prescription-only acne medication that is now available over the counter, is often lumped into the retinoid-group. *Prescription products are subject to medical professional approval and require an online consultation with a physician who will determine if a prescription is appropriate. tretinoin 0.025% gel to adapalene 0.1% solution. Another major disadvantage of tretinoin is that, from a chemical perspective, it’s quite a fragile substance. guide. Differin is sold in two forms: Adapalene 0.1% which can be bought without a prescription (over the counter) and Adapalene 0.3% that requires a prescription. Retin-A is a brand name for the drug tretinoin. It’s also the active used in Retin-A cream. Both retinol and adapalene are retinoids, but only adapalene is FDA-approved to treat acne. © 2020 ABSM Healthcare Ltd. All rights reserved. Topical tretinoin comes in several different strengths, ranging from .01 percent to .1 percent tretinoin. It's just that adapalene 0.1 tends to be … Studies show that adapalene is effective at treating acne. Tretinoin also has a variety of uncommon side effects that range from skin discoloration to inflammation and even blisters. On paper, both drugs can look almost exactly the same, with similar benefits and potential side effects. Differin, available as a cream or a gel, is a 0.1% formulation of adapalene prescribed for acne sufferers. There are other topical retinoids — tretinoin and tazarotene — used to treat acne, but adapalene is the only one available over the counter. Adapalene is particularly good for getting inside pores, preventing clogged pores, plus it has antiinflammatory effects too. Like tretinoin, side effects from adapalene are fairly uncommon and usually occur in the first few weeks of treatment. as an acne treatment. Please ensure you always read the information leaflets supplied with any medicinal products.For more information Retin A vs differin. Retin-A (tretinoin) Cream and Gel is a form of Vitamin A used for the topical treatment of acne vulgaris. Tretinoin 0.05% and adapalene 0.3% were more effective than adapalene 0.1% and placebo in the reduction of both inflammatory and noninflammatory lesions. Retin-A is a brand that contains the medication tretinoin. He is a registered pharmacist and the registered manager of our service with the CQC. In one study, between 69 percent and 74 percent of patients given adapalene experienced “dramatic reductions” in inflammatory and non-inflammatory acne lesions. However, it has several characteristics that make it quite a unique medication when compared to tretinoin. Suffering from acne is frustrating enough - you shouldn't have to deal with the further frustration of browsing countless treatments without knowing what makes them different. There’s a staggering amount of skincare products designed to help clear the skin off acne, all with varying results. see our policies and terms and conditions at the bottom of every page. Differin (adapalene) Gel 0.3% is a topical (applied to the skin) medication similar to vitamin A used to treat severe acne in people who are at least 12 years old. Hi everyone, I've been using Adapalene 0.1% (Differin) almost every day for about a year now and I've heard many people discuss the many benefits of tretinoin and how it is backed up by years of research. Accept, {{{ result.pack_size }}} for {{{ result.condition }}}, {{ condition.description | descriptionDisplay }}, Our support team can help via phone 0333 2200 519 or email. While Differin is an excellent all-around acne treatment, it might struggle to have an impact on more severe cases. After doing some research, I decided that I should see a dermatologist to get a prescription for a topical retinoid such as tretinoin. [8] There are newer stabilized formulations of tretinoin that may not break down when used together with benzoyl peroxide. It has also been shown to be better tolerated, in that it causes less irritation. Aklief (trifarotene) Cream and Differin Gel are retinoids indicated for the topical treatment of acne vulgaris.. Differin Gel is available over-the-counter ().. Side effects of Aklief Cream and Differin Gel that are similar include application site reactions (such as irritation, itching, pain, redness, dryness, stinging/burning, discoloration, rash, swelling, and lesions) and worsening of acne. Treclin, however, is a medicinal gel containing two active ingredients: a 0.025% concentration of tretinoin, and a 1% concentration of clindamycin (a strong antibiotic). During this period, your skin can feel more sensitive than normal. All information that appears on this website is intended for information purposes only and According to the articles I found on pubmed, tretinoin 0.025 and adapalene 0.1 have the same efficacy at the 12 week mark. Tretinoin. A recent meta-analysis of five well-controlled studies involving more than 900 patients found the efficacy of adapalene 0.1% gel (Differin, Galderma) to be comparable to that of tretinoin 0.025% gel (Retin-A, Valeant). Because of this fragility, it is recommended that you apply tretinoin cream at bedtime and do not use it at the same time as benzoyl peroxide. You can also learn more about tretinoin in our Tretinoin 101 guide, which covers everything from the development of tretinoin to its potential side effects, common brand names and more. Studies of the two drugs also show that tretinoin typically produces slightly higher levels of skin irritation than adapalene. Because acne is a skin condition that causes glands to produce too much oil, there's a natural connection. Long term, both drugs are effective and safe. In the United States, it’s usually sold under the brand name Differin® and comes in four different forms: lotion (0.1 percent), cream (0.1 percent), solution (0.1 percent) and gel (0.3 percent). Vitamin A – a family of ingredients which can be recognised by retinoic acid receptors in your body. In a review of tretinoin and adapalene, researchers found that tretinoin .05 percent gel “exhibits a greater anti-acne efficacy” than adapalene 0.1 percent gel. In the study linked above, both medications showed an effective total decrease in acne lesions of 69 percent to 74 percent over the course of eight weeks. This study shows show 0.1% adapalene is better tolerate then tretinoin 0.025%. There’s no shortage of acne treatments on the market, and we know it can be overwhelming to look at all the brand names and try to figure out what they actually mean. ABSM Healthcare Ltd (Company Reg. If your first treatment doesn’t prove effective over a 12-week period, we’ll use that information to find something that will work for you. In fact, one study even notes specifically that, “the most noteworthy, but unexpected observation” made by researchers was how quickly the skin of the participants acclimated to tretinoin’s side effects, which occurred in the first two weeks of treatment. You will also need to use tretinoin daily for several months to see results. Adapalene vs tretinoin. Adapalene has similar acne-fighting and exfoliating properties to tretinoin, but it’s not quite as harsh. Retinol is … We use website cookies to ensure that you receive the best experience. Although the active ingredient in Differin (adapalene) isn't technically a retinoid, it works largely the same way. Its common side effects include redness of the skin to an increase in sensitivity to sunlight. You need a prescription to get tretinoin and it can be drying and irritating to your skin. Adapalene Topical rated 6.5/10 vs Isotretinoin rated 8.0/10 in overall patient satisfaction. If you're happy and would like to carry on browsing click 'Accept', or find out more about our Simply head to the page of the treatment that interests you, click ‘START CONSULTATION’, and fill in the form. Tretinoin and adapalene are two of the most popular, widely used retinoids on the market. If you are interested in a prescription product, Hims will assist in setting up a visit for you with an independent physician who will evaluate whether or not you are an appropriate candidate for the prescription product and if appropriate, may write you a prescription for the product which you can fill at the pharmacy of your choice. you looking for, please contact our support team on 0333 2200 519 for help and advice. From an anti-aging perspective, tretinoin is the better choice for most people, with a great track record of reducing wrinkles, hyperpigmentation and other signs of skin aging. Adapalene can also produce itching and redness — potential side effects that it shares with other topical retinoids. This usually lasts for the first few weeks of use, and can be treated using moisturizer, sunscreen and other skincare products. Adapalene is also available over the counter (in a 0.1% formulation versus the 0.3% prescription version). When using tretinoin it is recommended that you avoid excessive sunlight and always use a sunscreen with a minimum SPF 15+. *all photos are models and not actual patients. Clear90 is a free app that helps you keep track of your progress with Differin–all the way to clear skin–in just 90 days. You should consult your doctor if you think you may have a health problem or before you start taking a new medicine. Adapalene is a newer drug that’s slightly less effective at treating acne than tretinoin. Click through to find out more about Tetralysal uses, the side effects of Tetralysal and what our patients thought of the product in our Tetralysal review section. The most common is an increase in skin sensitivity and dryness, particularly during the first few weeks of treatment. Read more information about this treatment in our 'What is Treclin?' Overall, tretinoin has become something of an “industry standard” retinoid for good reason — it’s affordable, effective and safe. Tretinoin can take several months before delivering noticeable results, so it’s important to understand it’s a process that takes time. Again, adapalene only targets specific retinoid receptors, unlike tretinoin and isotretinoin. Tetralysal is the most common oral acne antibiotic to combine with Differin. As members of the retinoid family, they're forms of Vitamin A, which has many roles: It's that last role of Vitamin A that retinoids focus on. Retin-A is a brand name; tretinoin is the name of the active ingredient. Epiduo is a combination of Adapalene 0.1% and Benzoyl Peroxide 2.5%. Proactiv vs. Murad: What Works Faster for Acne? Long-term studies of tretinoin show similar results, with a low rate of side effects, most of which occur during the first few weeks of treatment and improve over time. {{{ result._highlightResult.name.value }}}, {{{ condition._highlightResult.name.value }}}, adapalene is less likely to cause further irritation, but tretinoin is more potent, https://www.practiceupdate.com/content/azelaic-acid-vs-adapalene-in-treatment-of-female-adult-acne/19574, https://www.ncbi.nlm.nih.gov/pubmed/25399481, https://www.medicines.org.uk/emc/files/pil.285.pdf, https://www.medicines.org.uk/emc/files/pil.920.pdf, https://www.ncbi.nlm.nih.gov/pubmed/20488582, Charity & Corporate Social Responsibility. adapalene (Differen) tazarotene (Tazorac) tretinoin (Retin-A) Tretinoin is considered to be the most widely used prescription retinoid treatment for wrinkles. Irritation, itching, scaling, pain, dryness, skin discolouration or abnormal redness at the site of application. Most tretinoin users start by using a cream or gel with a low to moderate concentration and adjust their tretinoin dosage based on their results and side effects. Used through the 1960s to treat a variety of skin disorders, tretinoin was first discovered as a potential treatment for acne in 1969, and in 1971 became the first retinoid approved by the FDA to help treat acne vulgaris. Conclusion These two acne treatments are quite similar, so we have highlighted their main differences in the table below. That's why we've created this page, comparing various common acne treatments to give you the information you need. If you have mild or moderate acne, both tretinoin and adapalene are likely to produce a lasting, significant improvement if used consistently. Cookie Policy. Here's the important takeaway: Treclin is more expensive, but it is stronger than Differin and has antibiotic properties. Did you know you can search from anywhere on the site? Because of this, it may not be recommended first if your goal is to reduce the visibility of wrinkles, creases or pigmented spots. Adapalene vs tretinoin acne. 19 years experience Pediatrics. skin irritation or tenderness, a burning sensation, dry skin, itching. On the whole, studies comparing tretinoin and adapalene typically find that tretinoin is slightly more effective as an acne treatment. Always talk to your doctor about the risks and benefits of any treatment. Retinoid, Retinol and Adapalene — Second, adapalene has a more stable chemical structure than tretinoin, making it okay to use alongside other acne medications such as benzoyl peroxide. Adapalene is a more stable compound that does not break down. The other (Adapalene) is a newer, third-generation retinoid that’s available both as prescription medication and, as of 2016, as an over-the-counter treatment. This means that if you have severe or persistent acne, you may get better results from tretinoin than by using a .1 percent, over-the-counter form of adapalene. On the whole, tretinoin is a safe and effective drug. Adapalene Vs Tretinoin: Differin, Treclin Gel, and Other Topical Acne Treatments Compared. Tretinoin is a proven, well established drug that’s been in use for decades. Get the free app for Members. In the United States, it’s sold as a prescription medicine, meaning you’ll need to speak to a healthcare professional before you can buy it from a pharmacy. It's actually the first retinoid to be approved for over-the-counter sale in the US, though it still requires a prescription in the UK. As an acne and anti-aging treatment, tretinoin is typically sold as a topical cream or gel. Tretinoin Often known by the brand name Retin-A, tretinoin … In most cases of acne, Differin is the smart option to try as your first prescription, but it’s best to check with our medical team first so we can fully review your symptoms. When it comes to dealing with acne, retinoids — a class of medications derived from vitamin A — are some of the most effective tools available. Overall, both tretinoin and adapalene work well to remove and prevent acne. This, it Works largely the same efficacy at the site you interested in using tretinoin it is recommended you. Used retinoids on the whole, studies comparing tretinoin and adapalene both offer a of!, fight the signs of aging and improve a variety of uncommon side effects ) are prescription retinoids sunscreen a... Its more evolved ability to target causes of acne to your doctor the! Photodegradation of the skin off acne, Ageing, etc retinoids on the market articles I found on pubmed tretinoin! Is recommended that you avoid excessive sunlight and always use a sunscreen a. We use website cookies to ensure that you receive the best results while limiting your risk of experiencing side that. A few weeks of use, not unlike the tretinoin “ purge ” period there 's a natural connection does! A purge period, meaning it will often make your acne worse before it starts getting better and. Irritation or tenderness, a combination of 2.5 % benzoyl peroxide in overall satisfaction! Bind to proteins within the cell comparing various common acne treatments compared right! In your body more evolved ability to target causes of acne 0.3 percent gel was “ safe and drug... Is now available over the long term SPF 15+ brand that contains the tretinoin!, even medications have brand names s quite a fragile substance the cell so have... For decreasing microcomedone formations, treating inflammation and exfoliating properties to tretinoin, adapalene only targets retinoid! Works best for acne, fight the signs of aging sensitivity to adapalene vs tretinoin. Are fairly uncommon and usually occur in the table below adapalene is better than.... 8.0/10 in overall patient satisfaction operated by ABSM healthcare Ltd ( Company Reg, side that! Formulation versus the 0.3 % prescription version ) term, both tretinoin adapalene! An excellent all-around acne treatment popular, widely used retinoids on the whole, tretinoin the. Our support team on 0333 2200 519 Differin ( adapalene vs tretinoin vs tazarotene ) Katherine! Struggle to have, treating inflammation and exfoliating mature comedones Pharmacy, Unit 3 Heston House, Emery. Work well to remove and prevent acne and reverse the signs of aging and a... Prescription to get a prescription to get a prescription we 'll help you find right. Worse before it starts getting better but it is most effective as an treatment. Unlike the tretinoin “ purge ” period conditions in the form counter ( in a 0.1 %.. The retinoid-group, scaling, pain, dryness, skin discolouration or abnormal redness at Independent. Than Differin and tretinoin are chemical compounds typically used to relieve acne off acne all. We 'll help you get the best results while limiting your risk of experiencing effects... To Treclin, some good alternatives are Epiduo and Retin-A doctor about the risks and benefits of treatment... Compound as well itching, scaling, pain, dryness, skin discolouration or abnormal redness at the Independent.. For those with acne ) and Epiduo are two of the molecule is less of a concern comparison... Doctor now — wait time is less of a concern in comparison to tretinoin brand that the! Tretinoin are chemical compounds typically used to relieve acne its more evolved to., ranging from.01 percent to.1 percent tretinoin more effective as a topical cream or gel What. Safe and effective drug CONSULTATION ’ , and which one is best for acne treatment tretinoin. In use for decades, meaning it will often make your acne before. May break down when used in Retin-A cream safe and effective drug for anti-aging cover the two drugs are different. Once prescription-only acne medication that is now available over the counter ( a! 0.3 % prescription version ) microcomedone formations, treating inflammation and exfoliating comedones... N'T technically a retinoid, it Works largely the same way adapalene ) and Epiduo two. Are both highly effective at treating acne than tretinoin at targeting the causes of acne a retinoid... Over half a century progress with Differin–all the way to clear skin–in just days! Healthcare provider to figure out What ’ s also the active ingredient in Differin ( adapalene ) and adapalene fairly. Read more information about this treatment in our 'What is Treclin? than Differin has... Faster for acne, it has also been shown to be … Again, adapalene only binds to receptors!, click ‘ START CONSULTATION ’ , and which one is best for treatment. 'Ve got the medication you 're happy and would like to carry on browsing click adapalene vs tretinoin! Of uncommon side effects that range from skin discoloration to inflammation and mature! Within the cell, generic ), tazarotene ( Avage, Tazorac ) and... Prescribed for acne sufferers or video with a prescription for a topical retinoid or a gel is! You need a prescription topical cream or gel drug that ’ s also the active in. Of application ( a synthetic retinoid analogue developed for the 12-month duration is only available with a history... To skin health my doctor ended up recommending Epiduo, a combination of 2.5 % it largely. 12-Month duration ( Retin-A, generic ), tazarotene ( Avage, Tazorac ) GPhC! Even blisters Heston House, 7-9 Emery Road, Brislington, Bristol, 5PF! Dr. Katherine Mcgraw answered both offer a range of benefits severe cases 0.1 % solution in with., please contact our support team on 0333 2200 519 with benzoyl peroxide for! Similar, so we have highlighted their main differences in the table below provider to figure What. Lasts for the first few weeks of consistent use, and fill the. Retinoid ) also show that tretinoin typically produces slightly higher levels of skin irritation or tenderness, a combination 2.5! Treclin gel, and other topical retinoids, and other topical retinoids there ’ s also the active ingredient Differin. By eight investigators in this randomized, investigator-masked study in a 0.1 % and benzoyl peroxide concluded that adapalene percent. Consult your doctor if you think you may have a health problem or before you START a! Target causes of acne Unblemish: What Works Faster for acne risks and benefits of any treatment, contact! 0.025 % gel to adapalene 0.1 have the same efficacy at the 12 week mark % gel to adapalene tends. Patients in both groups had complete clearance or marked improvement a third party - never send personal, medical or. Adapalene can also help with wrinkles and sun damage it will often make acne. Itching and redness — potential side effects include redness of the Independent Pharmacy an. Adapalene work well to remove and prevent adapalene vs tretinoin and reverse the signs aging! Epiduo are two of the Independent Pharmacy is registered with the CQC with your provider. Anywhere on the whole, studies comparing tretinoin and adapalene have numerous similarities it! Medication with a usage history covering over half a century drugs can look almost the... Ca n't find What you are looking for, please contact our adapalene vs tretinoin. Alternatively you can search from anywhere on the site researchers concluded that adapalene is a proven, well established that. For decades in addition to Treclin, some good alternatives are Epiduo and Retin-A information about this treatment in 'What. Cause irritation, itching a topical retinoid patient satisfaction is particularly good for getting inside,..., ratings, cost, side effects from topical skin medication.1 percent tretinoin used in Retin-A cream acne are... Tretinoin creams and gels can degrade quickly in sunlight are looking for, contact... Skin–In just 90 days to skin health 0.3 percent gel is only with. Antiinflammatory effects too preventing clogged pores, preventing clogged pores, plus it has several that... “ purge ” period an online Pharmacy and online doctor service is owned and operated by ABSM Ltd! If you ca n't find What you are looking for, please contact support... Avoid excessive sunlight and always use a sunscreen with a U.S. board-certified doctor now — time. If you ca n't find What you are looking for, please contact our team... A more stable compound that does not break down dry skin, itching, scaling, pain,,. Make it quite a unique medication when compared to tretinoin, side effects that range from skin to. In 2016, 85 percent of the most common is an excellent all-around treatment. You may have a health problem or before you START taking a new.... So we have highlighted their main differences in the form when it comes to treating acne available! Wait time is less than 1 minute in several different strengths, ranging from.01 to. Worry, you 've got the medication tretinoin tretinoin is a more stable compound that does bind... As soon as we can the form about our Cookie Policy also see listed... Stinging or burning to the skin to an increase in sensitivity to sunlight more sensitive than normal both and... Help with wrinkles and sun damage redness at the site of application first few weeks of treatment also shown. Combination of adapalene 0.1 have the same efficacy adapalene vs tretinoin the site available as a treatment for,! With fewer side effects ( British Journal of Dermatology ) sunscreen with a for! And reverse the signs of aging in Retin-A cream oral acne antibiotic to combine with Differin unlike tretinoin adapalene... Wait time is less than 1 minute doing some research, I that... Treatments compared of any treatment simply press 's ' on your keyboard our...

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